Peptidomimetic inhibitors of cathepsin d and plasmepsins i...

Details Peptidomimetic inhibitors of cathepsin d and plasmepsins i... Peptidomimetic inhibitors of cathepsin d and plasmepsins i...

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) C07C 237/22 (2006.01) C07D 255/02 (2006.01) C07D 285/00 (2006.01) C07F 9/6584 (2006.01) C07K 5/02 (2006.01) C07K 5/027 (2006.01) C07K 7/56 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2246758

The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria.

L'invention concerne la conception et la synthèse d'inhibiteurs linéaires et cycliques de cathépsine D et de plasmépsines I et II. L'invention porte également sur les utilisations de ces inhibiteurs pour la prévention de l'invasion et de la métastase des cellules cancéreuses. Elle porte en outre sur l'utilisation d'inhibiteurs de la cathépsine D et des plasmépsines I et II pour la prévention ou le traitement de la maladie d'Alzheimer et du paludisme.

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