Peptidomimetic inhibitors of cathepsin d and plasmepsins i...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/02 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) A61P 25/28 (2006.01) C07D 255/02 (2006.01) C07D 285/00 (2006.01) C07K 7/56 (2006.01)

Patent

CA 2412954

The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria.

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