Peptidyl compounds comprising an itim motif which regulate...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 14/705 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 19/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2247207

The present invention is directed to a novel product and method for regulating hematopoietic cell function and a novel product and method for identifying compounds capable of regulating inflammation. The present invention includes a method to regulate hematopoietic cell function by contacting a cell with a regulatory reagent capable of altering the activity of a molecule including PTP1C, PTP1D, ITIM-p160 and ITIM-p70. The present invention also relates regulatory reagents capable of regulating the activity of PTP1C, PTP1D, ITIM- p160 and ITIM-p70, including nucleic acid molecules having sequences that encode such reagents and antibodies raised against such reagents. The present invention also includes a therapeutic composition comprising such reagents and their use to protect animals from inflammation.

La présente invention concerne un nouveau produit et un nouveau procédé pour réguler une fonction des cellules hématopoïétiques, ainsi qu'un nouveau produit et un nouveau procédé pour identifier des composés capables de réguler les inflammations. La présente invention concerne un procédé destiné à réguler une fonction des cellules hématopoïétiques consistant à mettre une cellule en contact avec un réactif régulateur capable de modifier l'activité d'une molécule telle que PTP1C, PTPID, ITIM-p160 et ITIM-p70. La présente invention concerne également des réactifs régulateurs capables de réguler l'activité de PTP1C, PTP1D, ITIM-p160 et ITIM-p70, y compris des molécules d'acide nucléique présentant des séquences qui codent ces réactifs et des anticorps dirigés contre ces réactifs. La présente invention concerne également une composition thérapeutique contenant ces réactifs et son utilisation pour protéger des animaux contre les inflammations.

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