Peptidyl derivatives as inhibitors of interleukin-1.beta....

Details Peptidyl derivatives as inhibitors of interleukin-1.beta.... Peptidyl derivatives as inhibitors of interleukin-1.beta....

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2129976

Novel peptidyl derivatives of formula (I) are found to be potent inhibitors of interleukin-I.beta. converting enzyme (ICE). Compounds of formula (I) may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular sys- tem including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula (I) are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 func- tions as an autocrine growth factor or as a mediator of cachexia.

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