Peptidyl derivatives as inhibitors of interleukin-1beta...

Details Peptidyl derivatives as inhibitors of interleukin-1beta... Peptidyl derivatives as inhibitors of interleukin-1beta...

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 38/04 (2006.01) C07C 255/29 (2006.01) C07C 255/44 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2085300

223/CCP104 18639 TITLE OF THE INVENTION PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-l.beta. CONVERTING ENZYME ABSTRACT OF THE INVENTION Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-l.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. Image

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