Peptidyl derivatives as inhibitors of pro-apoptotic cysteine...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/023 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/033 (2006.01) C07K 5/113 (2006.01) C12N 9/64 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218389

Compounds having the formula (I): R1COAA1AA2AA3NHY are inhibitors of apopain, an enzyme involved in the process of apoptosis. These compounds are useful as research tools as well as in the treatment of any condition in which reduced apoptosis would be beneficial, including immune deficiency syndromes (including AIDS), type I diabetes, pathogenic infections, cardiovascular and neurological injury, alopecia, aging, Parkinson's disease and Alzheimer's disease.

L'invention concerne un composé de la formule (I): R?1¿COAA?1¿AA?2¿AA?3¿NHX. Ces composés sont des inhibiteurs de iapopaïne, une enzyme impliquée dans le processus d'apoptose. Ces composés sont utiles en tant qu'outils de recherche, ainsi que pour le traitement de différents troubles, où une diminution de l'apoptose serait bénéfice, en particulier les syndromes d'immunooléficience (en particulier le SIDA), le diabète type I, les infections par des pathogènes, les atteintes cardiovasculaires et neurologiques, l'alopécie, le vieillissement, la maladie de Parkinson et la maladie d'Alzheimer.

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