Peptidyl-prolyl cis-trans isomerase inhibitors and uses...

Details Peptidyl-prolyl cis-trans isomerase inhibitors and uses... Peptidyl-prolyl cis-trans isomerase inhibitors and uses...

C - Chemistry, Metallurgy

12

N

C12N 9/90 (2006.01) A61K 31/045 (2006.01) A61K 31/095 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/66 (2006.01) A61K 38/02 (2006.01) A61K 38/05 (2006.01) C07D 207/00 (2006.01) C07F 9/02 (2006.01) C07F 9/06 (2006.01) C07F 9/22 (2006.01) C12N 11/00 (2006.01) C12Q 1/533 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2334812

The invention relates to inhibitors of PPIase activity and pharmaceutical compositions containing such inhibitors. Such compounds are useful for treatment of disorders characterized by inappropriate cell proliferation. In particular the compounds disclosed herein inhibit the activity of members of the Pin1/parvulin class of PPIases. These compounds have been designed based on the high resolution X-ray derived crystal structure of the human enzyme Pin1.

L'invention porte sur des inhibiteurs de l'activité de la PPIase et des préparations pharmaceutiques les contenant. Ces composés, utiles pour le traitement de troubles caractérisés par une prolifération inappropriée des cellules, inhibent en particulier l'activité d'éléments de la classe Pin1/parviline des PPIases. Ils ont été conçus sur la base de la structure cristalline à haute résolution obtenue par des rayons X de l'enzyme humaine Pin1.

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