C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.04
C07K 5/087 (2006.01) C07K 5/065 (2006.01)
Patent
CA 1133897
ABSTRACT OF THE DISCLOSURE Novel peptidyl-arginine aldehyde derivatives and their salts of general formula I or Ia Image I wherein X represents a hydrogen atom, benzoyl or tert-butyloxycarbonyl group, and Y stands for a D-phenylalanine, .beta.-phenyl-D-lactic acid or D-allo-isoleucine residue, are prepared from peptidyl-arginine aldehydes protected by an urethan type protecting group on their N- or O-terminal and/or guanidino group, by removing the protecting group in a mixture of lower alkanols and water by means of hydrogenolysis, and eventually converting the product formed into a salt. The compounds of general formula I and Ia possess valuable antithrombin activity.
343115
Bagdy Daniel
Bajusz Sandor
Barabas Eva
Nee Hasenohrl Szell Erzsebet
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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