A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2185227
The percutaneous absorption applying sheet of the present invention relates to a percutaneous absorption applying sheet having a pressure- sensitive adhesive layer comprising a pressure-sensitive adhesive, an active ingredient and a percutaneous absorption enhancer, laid on a single surface a backing material, in which said active ingredient is an acid salt of morphine, and said percutaneous absorption enhancer is (A) an compound having a log P value (P represents partition coefficient in octanol/water system) of from -0.5 to 2Ø The percutaneous absorption applying sheet of the present invention can constantly release a pharmacologically acceptable acid salt of morphine uniformly for a long period, is excellent in percutaneous permeability and can be effectively applied to a patient having a symptom such as pain, cough, diarrhea or the like.
Emplâtre à absorption percutanée composé d'un support revêtu, d'un côté, d'une couche composée d'un adhésif sensible à la pression, d'un médicament et d'un accélérateur d'absorption percutanée. Ledit médicament est un sel d'addition d'acide de la morphine et l'accélérateur est un composé (A) présentant une valeur logarithmique P de -0,5 à 2,0 (P représentant le coefficient de séparation d'un système octanol/eau). L'emplâtre permet la diffusion régulière et uniforme d'un sel d'addition d'acide de morphine pharmaceutiquement acceptable sur une longue période avec une excellente pénétration percutanée; il permet de traiter efficacement des patients souffrant de douleurs, de toux, de diarrhée, etc.
Azuma Masato
Hashimoto Michiari
Kitamura Mikiya
Ota Tetsuya
Fetherstonhaugh & Co.
Sekisui Chemical Co. Ltd.
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