A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/159
A61K 47/22 (2006.01) C07D 317/12 (2006.01) C07D 317/16 (2006.01) C07D 317/20 (2006.01) C07D 319/06 (2006.01)
Patent
CA 1313619
1. NEW PERCUTANEOUS ABSORPTION ENHANCERS, COMPOSITIONS CONTAINING SAME AND METHOD OF USE ABSTRACT Novel 1,3-dioxacycloalkanes are provided along with new 1,3-dioxacycloalkane compositions which are useful in enhancing the absorption of therapeutic agents through the skin of humans and animals, The method for enhancing skin penetration of therapeutic agents using 1,3-dioxacycloalkanes is also described. The preferred compounds are 1,3-dioxacycloalkanes (1,3-dioxacycloalkanes) and 1,3-dioxanes (1,3-dioxacyclohexanes). The preferred compounds have the formula: Image wherein R, R0, R1, R2, R3, R4, R5, and R6 are each independently selected from hydrogen and C1 and C18 aliphatic groups, preferably alkyl, alkenyl, halo, hydroxy, carboxy, carboxamide, and carboalkoxy substituted forms thereof, with at least one of said R's an alkyl or alkenyl group of C4 to C18 and n=0 or 1; the total number of carbon atoms in all of said R groups being no more than 40, and preferably less than 20 and not more then 1 thereof containing 18 or more carbon atoms.
551898
Daskalakis Stefanos
Samour Carlos M.
Macrochem Corp.
Smart & Biggar
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