Percutaneous administration device of bisoprolol

Details Percutaneous administration device of bisoprolol Percutaneous administration device of bisoprolol

A - Human Necessities

61

K

A61K 31/138 (2006.01) A61K 9/70 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 25/02 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2678424

A device for the administration of bisoprolol having a support; and a pressure-sensitive adhesive layer containing bisoprolol which is layered on one face of the support; wherein the maximum speed of releasing bisoprolol within 24 hours immediately after the application to the skin is 30 µg/cm2/h or less and the speed of releasing bisoprolol at the point 24 hours after the application to the skin is 10 µg/cm2/h or less. This transdermal administration device shows a relived skin irritation at the application and, in particular, at the peeling and enables the continuous administration of a therapeutically or preventively effective amount of bisoprolol to the living body.

L'invention concerne un dispositif pour l'administration de bisoprolol ayant un support ; et une couche d'adhésif sensible à la pression contenant du bisoprolol qui est déposé en couche sur une face du support, la vitesse maximale de libération du bisoprolol dans les 24h immédiatement après l'application sur la peau étant de 30 µg/cm2/h ou moins et la vitesse de libération du bisoprolol au point 24 heures après l'application sur la peau étant de 10 µg/cm2/h ou moins. Ce dispositif d'administration transdermique montre une irritation de la peau soulagée à l'application et, en particulier, au pelage et permet l'administration continue d'une quantité efficace des points de vue thérapeutique et préventif du bisoprolol au corps vivant.

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