Percutaneous-administration-type pharmaceutical preparation...

A - Human Necessities – 61 – M

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A61M 37/00 (2006.01) A61K 9/70 (2006.01) A61K 31/21 (2006.01) A61L 15/58 (2006.01)

Patent

CA 1304296

- 40 - ABSTRACT OF THE DISCLOSURE A percutaneos-administration-type pharma- ceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure- sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the contains as major copolymer weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.

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