A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/159, 167/255
A61K 47/32 (2006.01) A61K 9/70 (2006.01) A61K 31/21 (2006.01) A61L 15/58 (2006.01)
Patent
CA 2039869
A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin. Moreover, the preparation can be manufactured at low cost without any complicated process.
Préparation pharmaceutique de nitroglycérine de type à administration percutanée. La préparation comporte un support imperméable aux médicaments et une couche adhésive autocollante placée sur l'une des surfaces du support; la couche adhésive autocollante renferme un copolymère de (méth)acrylate d'alkyle à une concentration de 35-85 % en poids, de la nitroglycérine à une concentration de 10-30 % en poids, et de l'anhydride d'acide silicique à une concentration de 5-20 % en poids; le (co)polymère contient comme principaux constituants (co)polymériques des (méth)acrylates d'alkyle, avec des groupes alkyle possédant 6 atomes de carbone ou plus; ces (méth)acrylates d'alkyle comprennent le méthacrylate de 2-éthylhexyle à une concentration de 40-100 % en poids, en prenant comme base le poids total desdits (méth)acrylates d'alkyle. La préparation rend possible l'absorption de nitroglycérine par voie percutanée, à un taux régulé pendant une période prolongée. De plus, même une préparation compacte peut fournir une quantité suffisante de nitroglycérine. Enfin, la préparation peut être produite à un coût peu élevé sans processus compliqué.
Ishida Tsutomu
Kurono Masayasu
Nakagawa Takashi
Nakano Mitsuji
Sato Makoto
G. Ronald Bell & Associates
Sanwa Kagaku Kenkyusho Co. Ltd.
Sekisui Kagaku Kogyo Kabushiki Kaisha
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