Percutaneous and perungual delivery system

Details Percutaneous and perungual delivery system Percutaneous and perungual delivery system

A - Human Necessities

61

K

A61K 31/203 (2006.01) A61K 8/67 (2006.01) A61K 8/73 (2006.01) A61K 8/81 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/13 (2006.01) A61K 31/136 (2006.01) A61K 31/137 (2006.01) A61K 47/00 (2006.01) A61K 47/30 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61P 17/10 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61Q 3/00 (2006.01) A61Q 17/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2491078

The invention relates to a substantially homogeneous liquid composition capable of percutaneous delivery of one or more physiologically active agents, the composition including at least one physiologically active agent, a volatile solvent, and a rate modulating carrier comprising a hydrophilic polymer and a hydrophobic polymer the combination of the hydrophilic and hydrophobic polymers being elected to enable modulation of the rate of physiologically active agent. The invention also relates to method of delivering an effective amount of an active agent and method of treatment of a patient using the composition of the invention.

L'invention concerne une composition liquide sensiblement homogène pouvant administrer par voie percutanée un ou plusieurs agents physiologiquement actifs. Cette composition comprend au moins un agent physiologiquement actif, un solvant volatil, et un support de modulation de vitesse comprenant un polymère hydrophile et un polymère hydrophobe, la combinaison des polymères hydrophile et hydrophobe étant sélectionnée pour permette une modulation de la vitesse des agents physiologiquement actifs. L'invention concerne également une méthode d'administration d'une dose efficace d'un agent actif et une méthode de traitement d'un patient faisant intervenir ladite composition.

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