Percutaneous myocardial revascularization growth factor...

A - Human Necessities – 61 – B

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A61B 17/32 (2006.01) A61B 17/34 (2006.01) A61B 17/00 (2006.01) A61B 19/00 (2006.01) A61F 2/02 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2307102

The present invention is devices, and methods for increasing blood perfusion within the myocardium of the heart (20) by wounding the myocardium, and applying growth factors (34) to promote vascularization. One method includes driving spikes (66) into the myocardium from within the heart with the spikes(66) being formed of biodegradable material containing releasable growth factors (34) having lumens (70), and side holes (74). An alternative method promotes vascularization by injecting angiogenic material into holes (74) bored into the myocardium, and leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, and leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart, and applying a patch (90) including growth factors.

La présente invention concerne des dispositifs, ainsi que des procédés servant à accroître la circulation de sang dans le myocarde d'un coeur (20) par des lésions du myocarde et par l'application de facteurs (34) de croissance en vue d'activer une vascularisation. Un procédé comporte l'insertion de pointes (66) dans le myocarde à partir de l'intérieur du coeur, les pointes (66) étant constituées d'une matière biodégradable contenant des facteurs (34) de croissance et comportant des lumières (70) et des orifices (74) latéraux. Dans un autre procédé, on active la vascularisation en injectant une matière angiogénique à l'intérieur de trous (74) formés dans le myocarde, et en laissant un trou manifeste. Dans un autre procédé, on injecte une matière angiogénique à l'intérieur du myocarde sans former de trous, et sans laisser de trou manifeste. La matière angiogénique peut être contenue dans un adhésif biodégradable. On active une revascularisation du myocarde, dans un procédé, en blessant le coeur de façon externe et en appliquant un timbre (90) contenant des facteurs de croissance.

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