Percutaneously absorbable preparation

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/445 (2006.01) A61K 9/70 (2006.01) A61K 47/02 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2670991

[PROBLEMS] To provide a stable percutaneous absorption preparation for percutaneous absorption of donepezil or hydrochloride salt thereof that even at pasting, suppresses any drop of cohesion force of pressure sensitive adhesive layer and that also suppresses any adhesive residue by cohesion failure at stripping off. [MEANS FOR SOLVING PROBLEMS] The percutaneous absorption preparation is characterized by having a pressure sensitive adhesive layer containing 2-[(1-benzyl-4-piperidinyl)methyl]-5,6-dimethoxyindan- 1-one and/or its hydrochloride salt and a metal chloride, the pressure sensitive adhesive layer being crosslinked.

L'invention a pour objet de produire une préparation d'absorption percutanée stable de donépézil ou de sel de chlorhydrate de donépézil, qui, même au moment de l'application par collage, élimine toute baisse de la force de cohésion d'une couche d'adhésif autocollant, mais aussi tout résidu adhésif dû à un défaut de cohésion au moment de la désorption. La préparation d'absorption percutanée de l'invention se caractérise en ce qu'elle comprend une couche d'adhésif autocollant conternant 2 [(1-benzyl-4-pipéridinyl)méthyl]-5,6-diméthoxyindane-1-one et/ou son sel de chlorhydrate et un chlorure métallique, ladite couche d'adhésif autocollant étant réticulée.

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