Perfluoro-1h-1h-neopentyl containing contrast agents and...

Details Perfluoro-1h-1h-neopentyl containing contrast agents and... Perfluoro-1h-1h-neopentyl containing contrast agents and...

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07C 17/14 (2006.01) C07C 17/26 (2006.01) C07C 45/00 (2006.01) C07C 57/58 (2006.01) C07C 69/65 (2006.01) C07C 211/29 (2006.01) C07C 229/36 (2006.01) C07C 229/42 (2006.01) C07C 237/06 (2006.01) C07F 5/00 (2006.01) C07F 9/10 (2006.01)

Patent

CA 2158279

Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H neophentyl moiety are provided. The perfluo-1H, 1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3",5"-di[2"',2"'-di(trifluoromethyl)3"',3"',3"'- trifluoropropyl]phenyl}heptanoate), In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.

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