A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/285
A61K 31/025 (2006.01) A61K 9/00 (2006.01) A61K 47/00 (2006.01)
Patent
CA 1042799
ABSTRACT OF THE DISCLOSURE Perfluorocyclocarbons and emulsions containing emulsified particles of these perfluorocarbons are useful in supporting life as intravascular oxygen and carbon dioxide transport agents. Stable emulsions of perfluorocarbocyclic derivatives are prepared for use as artificial bloods and perfusates for organs. Intravenously infused emulsions containing perfluorocyclocarbons such as perfluoro(methylcyclo- hexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(deca- hydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), and the like, serve as intravascular oxygen and carbon dioxide transport agents. Fluorocarbon liquids are also useful as an external respira- tion media for transporting oxygen-carbon dioxide necessary to support intravascular respiration. Perfluorocyclocarbons have been found after intravenous emulsion infusion as artificial bloods to collect in the reticuloendothelial system (RES) of the animal body. However, it has also been found that perfluorocyclocarbon compounds leave the RES of the animal body and certain of these compounds, e.g., perfluoro(decahydronaphthalene), leave the RES at a much faster rate than others. Furthermore, after the intravenously infused perfluorocyclocarbon emulsions function as artifi- cial bloods, the perfluorocyclocarbons have the capability of leaving the animal body through the tissue, e.g., the lungs and skin. The invention described herein was made in the course of work under a grant from the Department of Health, Education and Welfare.
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