A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/02 (2006.01) A61L 27/36 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2248212
A perforated unitary multi-laminar tissue graft construct and method for preparing such construct are described. The method comprises overlapping strips of submucosal tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosal sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
Construction de greffon en tissu stratifié perforé en une seule pièce et procédé d'élaboration de cette construction. La méthode consiste à superposer des bandes de tissu sous muqueux avec d'autres bandes de tissu sous muqueux, à comprimer au minimum les secteurs se recouvrant desdites bandes entre deux surfaces dans des conditions de nature à permettre ou favoriser la déshydratation des couches sous muqueuses comprimées, et à perforer la construction ainsi obtenue de greffons de tissu en une seule pièce. Ces compositions de greffon de tissu perforé présentent des caractéristiques améliorées sur le plan de la résistance mécanique et à l'aptitude au remodelage par rapport aux greffons de tissu sub muqueux non perforé.
Badylak Stephen F.
Cheng Boyle
Whitson Bryant
Methodist Health Group Inc.
Purdue Research Foundation
Smart & Biggar
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