Pericardial tissue implants and methods of making them

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61L 27/36 (2006.01) A61F 2/14 (2006.01)

Patent

CA 2324958

An implant material in the form of a natural animal tissue cross-linked into a pre-formed shape, the tissue being adapted to substantially retain its shape when implanted into a body. Suitable tissues include fibro- serous membranes such as pericardium. Suitable cross-linking agents include aldehydes (e.g., glutaraldehyde), epoxides, isocyanates, carbodiimides, isothiocyanates, glycidalethers, and acyl azides. The implant material can be processed in either the supple or non-supple form, by the judicious use of ethanol and/or other dehydrating solutions in the course of its processing.

L'invention porte sur un matériau pour implant sous forme de tissu animal naturel réticulé en préforme et conçu pour conserver sensiblement sa forme lors de son implantation. Les tissus idoines comprennent des membranes fibro-séreuses telles que le péricarde. Les agents réticulants idoines incluent des aldéhydes (par exemple la glutaraldéhyde), des époxydes, des isocyanates, des carbodiimides, des isothiocyanates, des esthers glycidiques, et des acyl-azides. Le matériau pour implant peut être fourni sous forme souple ou non souple en dosant judicieusement l'éthanol ou d'autres solutions déshydratantes pendant son traitement.

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