A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2752157
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally--soluble bioactive agents such as, but not limited to, proteins of the TGF-.beta. superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally- invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.
La présente invention concerne des procédés et des compositions destinés à mettre en uvre l'administration systémique d'agents bioactifs très faiblement solubles et notamment, mais de manière non limitative, de protéines de la superfamille du TGF-ß via un mode périphérique d'administration. Un agent bioactif donné à titre d'exemple dans la présente invention est le BMP-7. L'invention porte en outre sur un traitement systémique peu invasif des troubles squelettiques, notamment de l'ostéoporose, ainsi que sur un traitement systémique peu invasif des tissus et organes non minéralisés malades ou lésés, notamment les reins. L'invention permet d'éliminer les effets secondaires indésirables au niveau du site périphérique d'administration par voie intraveineuse de l'agent bioactif.
Goad Mary Elizabeth Pecquet
Haskell Melissa M.
Schrier Denis
Wood Susan A.
Mbm Intellectual Property Law Llp
Stryker Corporation
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