A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/551 (2006.01)
Patent
CA 2332825
Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline derivatives, such as PK 11195, and benzodiazepine derivatives such as Ro 5- 4864. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are described. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.
L'invention concerne des composés qui se lient avec forte affinité aux récepteurs périphériques de la benzodiazépine utiles comme agents anti-inflammatoires. Ces composés contiennent des dérivés d'isoquinoline, tels que PK 11195 et des dérivés de benzodiazépine, tels que Ro 5-4864. L'invention concerne également un procédé de traitement d'une maladie inflammatoire chez un mammifère à l'aide de ces composés et des compositions pharmaceutiques renfermant ces composés. Fait aussi l'objet de cette invention un procédé d'identification de composés thérapeutiquement efficaces pour le traitement des maladies inflammatoires.
Klegeris Andis
Mcgeer Edith G.
Mcgeer Patrick L.
Waterfield J. Douglas
Klegeris Andis
Mcgeer Edith G.
Mcgeer Patrick L.
Oyen Wiggs Green & Mutala Llp
University Of British Columbia
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