Peripheral cannabinoid receptor (cb2) selective ligands

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 311/80 (2006.01) A01N 43/16 (2006.01) A61K 31/35 (2006.01) C07D 311/78 (2006.01)

Patent

CA 2387764

Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy.

La présente invention concerne de nouveaux analogues de cannabinoïdes polycycliques qui présentent de préférence de grandes affinités avec les sites de récepteurs CB2 de cannabinoïdes. Cette affinité avec les récepteurs améliorée rend ces analogues utiles d'un point de vue thérapeutique, en tant que médicaments pour des individus et des animaux, permettant de traiter la douleur, le glaucome, l'épilepsie et les nausées associées à la chimiothérapie.

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