Peripheral opioid receptor antagonists and uses thereof

Details Peripheral opioid receptor antagonists and uses thereof Peripheral opioid receptor antagonists and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 489/04 (2006.01) A61K 31/439 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2682125

The present invention provides a compound of formula I: wherein R1, R2, R2' and X' are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.

La présente invention concerne un composé de la formule I, dans laquelle R1, R2, R2 et X' sont tels que définis et décrits ici, et des compositions de celui-ci, utiles en tant qu'antagonistes de récepteurs opioïdes périphériques de type mu.

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