C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/55 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2325445
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer.
Les chercheurs ont découvert que l'expression et la localisation infracellulaire des récepteurs des benzodiazépines de type périphérique (PBR) sont corrélées au potentiel métastatique des cellules, et à une augmentation de la prolifération cellulaire. L'inhibition de l'expression, de la fonction et de la stabilité des PBR entraîne un ralentissement de la prolifération cellulaire. L'invention concerne des compositions et de méthodes de régulation et/ou de surveillance des PBR et de leur expression en vue de la détection, du diagnostic, du pronostic et du traitement des tumeurs solides, en particulier du cancer du sein.
Culty Martine
Papadopoulos Vassilios
Georgetown University
Georgetown University Medical Center
Mbm Intellectual Property Law Llp
LandOfFree
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