Peripheral-type benzodiazepine receptor associated proteins,...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61P 3/06 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339328

The present invention relates to nucleic acids encoding PBR-associated proteins (PAPs) and methods for use in producing PAPs and methods of using PAPs. In this study we have identified proteins (PAPs) that interact with PBR protein by a yeast two-hybrid system. We used PBR as bait to screen a mouse testis cDNA library. Five clones were isolated based on their ability to interact with PBR. These proteins may be involved in the regulation of the function of PBR, serving as an endogenous ligand or allosteric modulator of the receptor.

L'invention a trait à des acides nucléiques codant pour des protéines (PAP) associées au récepteur de benzodiazépine du type périphérique (PBR), à des procédés utiles pour produire des PAP et à des procédés d'utilisation de PAP. Les protéines (PAP) identifiées dans cette étude interagissent avec une protéine de PBR par un système de deux hybrides de levure. Le PBR a été utilisé comme amorce pour cribler une bibliothèque d'ADNc de testicule de souris. Cinq clones ont été isolés sur la base de leur capacité à interagir avec PBR. Ces protéines peuvent être impliquées dans la régulation de la fonction de PBR, servant de ligand endogène ou d'effecteur allostérique du récepteur.

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