A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 31/718 (2006.01) A61P 7/08 (2006.01)
Patent
CA 2319561
The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrine respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.
L'invention concerne une solution de dialyse péritonéale contenant des agents osmotiques stables, tels que des D-glucitols, des acides gluconiques et des alkylglycosides produits respectivement par la réduction, l'oxydation ou la glycosylation de l'icodextrine. En conséquence, ces agents osmotiques sont stables dans des conditions de stérilisation par la chaleur ou en autoclave, et ils permettent de réduire la dose de matériaux biologiquement incompatibles dans les solutions de dialyse péritonéale. L'invention concerne encore des procédés de préparation des D-glucitols, des acides gluconiques et des alkylglycosides.
Casu Benito
Naggi Annamaria
Petrella Enrico
Torri Giangiacomo
Baxter International Inc.
Sim & Mcburney
LandOfFree
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