Perivascular mesenchymal precursor cells

Details Perivascular mesenchymal precursor cells Perivascular mesenchymal precursor cells

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 5/077 (2010.01)

Patent

CA 2520273

Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilising a perivascular marker. A new mesenchymal precursor cell phenotype is described characterised by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-l and STRO-1bri . The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.

L'invention concerne des cellules précurseurs mésenchymateuses isolées dans des niches périvasculaires d'une gamme de tissus au moyen d'un marqueur périvasculaire. Un nouveau phénotype de cellule précurseur mésenchymateuse se caractérise par la présence du marqueur périvasculaire 3G5, et de préférence également de l'actine des muscles lisses avec des marqueurs de développement précoces tels que MUC18, VCAM-1 et STRO-1?bri¿. La cellule précurseur mésenchymateuse, multipotentielle, permet de former du tissu vasculaire ainsi que la moelle osseuse, la dentine et la pulpe. L'invention concerne enfin un procédé d'enrichissement faisant appel au tri cellulaire sur la base de ces marqueurs.

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