Perivascular wraps

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61L 31/06 (2006.01) A61F 2/00 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2497349

The present invention provides compositions, devices, and methods for maintaining or improving the integrity of body passageways following surgery, such as at a graft site, or injury. Delivery devices including one or more therapeutic agents and a mesh are described. Representative examples of therapeutic agents include microtubule stabilizing agents, anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non- steroidal anti-inflammaory drugs, and other factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder the optimal functioning of the passageway or cavity.

La présente invention concerne des compositions, des dispositifs et des procédés qui permettent de préserver ou d'améliorer l'intégrité de passages corporels après une opération chirurgicale, par exemple sur le site d'une greffe ou d'une blessure. L'invention se rapporte également à des dispositifs de distribution comprenant un ou plusieurs agents thérapeutiques et un filet. Des exemples représentatifs d'agents thérapeutiques comprennent des agents stabilisateurs de microtubules, des facteurs anti-angiogéniques, des inhibiteurs de la croissance ou de la prolifération cellulaire des muscles lisses, des médicaments anti-inflammatoires non stéroïdiens, et d'autres facteurs utilisés pour prévenir et/ou réduire une réponse biologique proliférative susceptible d'obstruer le passage ou la cavité ou d'entraver leur fonctionnement optimal.

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