A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 49/00 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2653456
This relates to a discovery of a cell surface protein, namely NgR2, that is implicated in regulation of blood-brain barrier (BBB). In addition, the invention relates methods for identifying agents that modulate BBB permeability. Furthermore, the invention relates to methods of delivering therapeutic agents to the central nervous system by increasing BBB permeability.
La présente invention concerne une découverte d'une protéine de surface, à savoir la NgR2, qui est impliquée dans la régulation de la barrière hémato-encéphalique. L'invention concerne également des procédés d'identification d'agents modulateurs de la perméabilité de la barrière hémato-encéphalique. L'invention concerne en outre des procédés d'administration d'agents thérapeutiques au système nerveux central en augmentant la perméabilité de la barrière hémato-encéphalique.
Barres Benjamin
Daneman Richard
Borden Ladner Gervais Llp
The Board Of Trustees Of The Leland Stanford Junior University
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