Permeabilizing biofilms

C - Chemistry – Metallurgy – 08 – J

Patent

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C08J 7/12 (2006.01) A61K 9/70 (2006.01) A61M 31/00 (2006.01) B01J 19/08 (2006.01) B05D 3/06 (2006.01) B05D 5/04 (2006.01) C08J 5/18 (2006.01)

Patent

CA 2373447

Methods for permeabilizing biofilms using stress waves are described. The methods involve applying one or more stress waves to a biofilm, e.g., on a surface of a device or food item, or on a tissue surface in a patient, and then inducing stress waves to create transient increases in the permeability of the biofilm. The increased permeability facilitates delivery of compounds, such as antimicrobial or therapeutic agents into and through the biofilm.

L'invention concerne des procédés de perméabilisation de biofilms faisant appel à des ondes de contrainte et consistant à appliquer une ou plusieurs ondes de contrainte sur un biofilm, par exemple sur une surface d'un dispositif ou d'un produit alimentaire, ou encore sur une surface tissulaire d'un patient, puis à induire des ondes de contrainte pour provoquer des augmentations transitoires de la perméabilité du biofilm. Cette amélioration de la perméabilité facilite la distribution de composés, notamment des agents antimicrobiens ou thérapeutiques dans et à travers le biofilm.

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