Permucosal composition and method of improving permucosal...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 38/21 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2577336

A permucosal composition designed so that a pharmacologically active peptide or protein is efficiently absorbed through a mucosa such as pulmonary mucosa, nasal mucosa, mouth mucosa, vaginal mucosa, ocular mucosa, gastric mucosa, or the mucosa of digestive tract. The permucosal composition is prepared by incorporating the following ingredients (i) and (ii): (i) at least one member selected from the group consisting of physiologically active peptides and proteins; and (ii) at least one member selected from the group consisting of chitosanoligosaccharides having a degree of polymerization of 2-20, derivatives thereof, glucosamine, and salts of these.

L'invention concerne une composition permuqueuse conçue de façon à ce qu'un peptide ou une protéine actifs du point de vue pharmacologique soient absorbés de façon efficace à travers une muqueuse telle qu'une muqueuse pulmonaire, une muqueuse nasale, une muqueuse de la bouche, une muqueuse vaginale, une muqueuse oculaire, une muqueuse gastrique ou une muqueuse du tube digestif. On prépare la composition permuqueuse en incorporant les ingrédients (i) et (ii) suivants : (i) au moins un élément sélectionné dans le groupe constitué de peptides et protéines physiologiquement actifs ; et (ii) au moins un élément sélectionné dans le groupe constitué d'oligosaccharides de chitosane ayant un degré de polymérisation de 2-20, de dérivés de ceux-ci, de la glucosamine et de sels de ceux-ci.

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