Pernasal composition and pernasal preparation containing the...

A - Human Necessities – 61 – K

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A61K 47/10 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174324

A pernasal composition comprising a pharmacologically active substance, water and an alcohol, wherein the alcohol content is 10-70 vol. % of the whole composition. This composition is highly safe and permits rapid drug absorption and prolonged retention of blood drug level. Hence this composition and a pernasal preparation containing the same permit pernasal administration of drugs, which have been difficult to administer pernasally, and are expected to exhibit satisfactory drug efficacy.

Composition administrée par voie nasale comprenant une substance pharmacologiquement active, de l'eau et un alcool, la teneur en alcool constituant 10 à 70 % en volume de la composition totale. Cette composition est sans aucun danger et permet une absorption rapide du principe actif ainsi qu'une rétention prolongée du niveau de médicament dans le sang. Ladite composition, ainsi qu'une préparation administrée par voie nasale la contenant, permettent l'administration par voie nasale de principes actifs jusqu'ici difficiles à administrer par cette voie.

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