Peroral composition for controlled release in the lower...

Details Peroral composition for controlled release in the lower... Peroral composition for controlled release in the lower...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/50 (2006.01) A61K 31/12 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01)

Patent

CA 2213747

The invention relates to a composition in the form of an enteric matrix granules coated with an enteric coating. The composition releases the drug gradually in the lower gastrointestinal tract, where the drug has local action in diseases of the lower gastrointestinal tract. The composition is especially suitable for the administration of 3-(3-cyanophenyl)methylene-2,4-pentanedione into the colon.

L'invention concerne une composition qui se présente sous la forme de granulés à matrice entéro-soluble enrobée dans un pelliculage gastro-résistant. La composition libère le médicament progressivement dans le tractus gastro-intestinal bas, ce qui permet un traitement médicamenteux local des maladies de ce secteur. La composition se prête particulièrement bien à l'admistration de 3-(3-cyano-phényle)méthylène-2,4-pentanédione au niveau du colon.

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