Peroral preparation of acid-unstable compound

Details Peroral preparation of acid-unstable compound Peroral preparation of acid-unstable compound

A - Human Necessities

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A61K 31/44 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)

Patent

CA 1336958

A peroral preparation of an acid-unstable compound comprises (1) a core containing the acid-unstable compound, (2) a first layer, coated on the core, comprising a hardly water- soluble, film-forming material and fine particles of a hardly water-soluble substance, suspended in the material, and (3) a second layer, coated on the first layer, of enteric film. The acid-unstable compound is preferably a benzimidazole compound. The acid-unstable compound in the preparation remains stable even under moist conditions.

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