Persephin and related growth factors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 16/26 (2006.01) C07K 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2225913

A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

L'invention concerne un nouveau facteur de croissance, la perséphine, qui appartient à la famille de la neurturine/GDNF des facteurs de croissance. Les séquences d'acides aminés du rat et de la souris ont été identifiées. Les séquences d'ADN génomique de la perséphine du rat et de la souris ont été clonées et mises en séquences, et les séquences d'ADNc respectives identifiées. En outre, l'invention a pour objet des procédés pour traiter les états de dégénérescence à l'aide de la perséphine, des procédés pour détecter les altérations du gène de la perséphine, et des procédés pour détecter et contrôler les taux de perséphine des patients. L'invention traite aussi de procédés pour identifier les membres supplémentaires de la famille de la perséphine-neurturine-GDNF des facteurs de croissance.

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