Persephin and related growth factors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C07K 16/26 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2296045

A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

L'invention se rapporte à un nouveau facteur de croissance, la perséphine, qui fait partie de la famille GDNF/neurturine des facteurs de croissance. On a identifié des séquences d'acides aminés de l'humain, du rat et de la souris. Les séquences d'ADN génomique de la perséphine chez l'humain, le rat et la souris ont été clonées et mises en séquences, et l'on a identifié les séquences de l'ADN-c correspondants. En outre, l'invention se rapporte à des procédés pour traiter à la perséphine les états de dégénérescence, à des procédés pour détecter les altérations du gène de la perséphine et à des procédés pour détecter et surveiller le taux de perséphine des patients. L'invention concerne également des procédés pour identifier d'autres membres de la famille de la perséphine-neurturine-GDNF des facteurs de croissance.

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