C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2142884
2142884 9404195 PCTABS00030 A medically important and useful conjugate comprising pertussis toxin (PT), or another antigen having similar physico-chemical properties, as the carrier protein component, coupled to a neutral or non-charged saccharide, particularly, the capsular polysaccharide of Streptococcus pneumoniae type 14 (Pn14), for use as an effective, non-toxic, and highly immunogenic vaccine is described. The invention is directed to a novel synthetic scheme wherein PT and like proteins, and a derivative of Pn14, and the like, were coupled at acidic pH via carbodiimide-mediated condensation to produce an immunogenic conjugate. The coupling procedure yielded a Pn14-PT conjugate in which the PT component was rendered non-toxic and both the PT and Pn14 components were immunogenic, as determined by the production of protective levels of both type-specific and neutralizing antibodies in mammals. The Pn14-PT conjugate was used as an immunogen at levels estimated to be protective in humans and stands to provide an effective, safe, and potent human vaccine.
Levi Lily
Robbins John B.
Schneerson Rachel
Smart & Biggar
The Government Of The United States Of America
LandOfFree
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