Pestivirus mutants and vaccines containing the same

Details Pestivirus mutants and vaccines containing the same Pestivirus mutants and vaccines containing the same

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/12 (2006.01) A61K 39/39 (2006.01) C07K 14/18 (2006.01) C12N 7/08 (2006.01)

Patent

CA 2342305

The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5' nontranslated region of the viral genome. These mutant viruses are useful as live vaccines in the control of bovine viral diarrhea, border disease and classical swine fever.

La présente invention porte sur des pestivirus mutants atténués, qui se répliquent moins bien comme l'indique la petite taille des plaques. Les mutations se situent dans la région 5' non traduite du génome viral. Ces virus mutants sont utiles en tant que vaccins vivants dans la lutte contre la diarrhée bovine d'origine virale, la maladie de la frontière et la peste porcine classique.

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