Pf4 pharmacophores and their uses

Details Pf4 pharmacophores and their uses Pf4 pharmacophores and their uses

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 31/167 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2588273

The invention provides a novel PF4 pharmacophore that is useful, inter alia, for identifying peptidomimetics and other compounds capable of modulating PF4 activity (e.g., as inhibitors, agonists or antagonists). Mutant PF4 polypeptide sequences are also provided that modulate PF4 activity in cells

L'invention concerne un nouveau pharmacophore PF4 utilisé, entre autres, dans l'identification d'agents peptidomimétiques et d'autres composés pouvant moduler l'activité de PF4 (par exemple, en tant qu'inhibiteurs, agonistes ou antagonistes). L'invention concerne également des séquences polypeptidiques PF4 mutantes modulant l'activité de PF4 dans les cellules.

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