Pfks as modifiers of the igfr pathway and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 9/12 (2006.01)

Patent

CA 2568331

Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided.

L'invention concerne des gènes PFK humains identifiés comme modulateurs de la voie IGFR et, par conséquent, comme cibles thérapeutiques pour des troubles associés à une fonction IGFR défectueuse. L'invention concerne également des méthodes destinées à identifier des modulateurs d'IGFR et consistant à rechercher par criblage des agents modulant l'activité de PFK.

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