C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C12N 15/10 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2353086
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
La présente invention concerne des molécules d'acides nucléiques qui ont été isolées sous le nom de PGC-1, et qui codent des protéines capables de moduler diverses activités associées aux adipocytes telles que, d'une part la thermogenèse des adipocytes, et notamment des adipocytes des tissus adipeux bruns, et d'autre part l'adipogenèse. L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression par recombinaison contenant ces molécules d'acides nucléiques PGC-1, des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression, et des animaux transgéniques non humains chez lesquels un gène du PGC-1 a été introduit ou ouvert. L'invention concerne en outre des protéines de PGC-1, des protéines de fusion, des peptides antigéniques, et des anticorps anti-PGC-1. L'invention concerne enfin des diagnostics, des criblages, et des traitements utilisant les compositions de l'invention.
Adelmant Guillaume
Puigserver Pere
Spiegelman Bruce M.
Wu Zhidan
Dana-Farber Cancer Institute Inc.
Gowling Lafleur Henderson Llp
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