Pgc-1, a novel brown fat ppar.gamma. coactivator

Details Pgc-1, a novel brown fat ppar.gamma. coactivator Pgc-1, a novel brown fat ppar.gamma. coactivator

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2290944

The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

La présente invention se rapporte à des molécules d'acides nucléiques isolées, appelées molécules d'acide nucléique PGC-1, qui codent des protéines pouvant moduler différentes activités liées aux adipocytes, par exemple, la thermogenèse chez les adipocytes, notamment les adipocytes bruns, et l'adipogenèse. L'invention concerne également des molécules antisens d'acide nucléique, des vecteurs d'expression recombinants renfermant des molécules d'acide nucléique PGC-1, des cellules hôtes dans lesquelles on a introduit les vecteurs d'expression, ainsi que des animaux transgéniques dans lesquels on a introduit ou rompu un gène PGC-1. Par ailleurs, l'invention se rapporte à des protéines PGC-1 isolées, à des protéines de fusion, à des peptides antigéniques et à des anticorps anti-PGC-1, ainsi qu'à des procédés diagnostiques, thérapeutiques et des procédés de sélection utilisant les compositions de cette invention.

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