Pgd2 receptor antagonists for the treatment of inflammatory...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/14 (2006.01) A61K 31/4353 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 215/48 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2500582

Disclosed herein are compounds represented by Structural Formula (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 ("CRTH2") for the treatment of inflammatory disorders.

L'invention concerne des composés représentés par la formule structurelle (I), dont les variables sont telles que définies dans la description. L'invention concerne également l'utilisation de ces composés pour inhiber le récepteur couplé à la protéine G, que l'on appelle molécule homologue au récepteur chimiotactique exprimée sur Th2 ("CRTH2"), dans le traitement de maladies inflammatoires.

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