C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/44 (2006.01) A61K 31/4709 (2006.01) A61P 29/00 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2561564
Disclosed herein are compounds represented by Structural Formula: (I) and (I- A). Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply "CRTH2" for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
La présente invention a trait à des composés de formule structurelle (I) et (I-A). L'invention a également trait à l'utilisation de tels composés pour l'inhibition de récepteur couplé à une protéine G désigné molécule homologue de récepteur à fonction chimioattractive exprimée sur le Th2, ou simplement CRTH2' pour le traitement de troubles inflammatoires. Les variables de la formule structurelle (I) et (I-A) sont tels que définis dans la description.
Carson Kenneth G.
Elder Amy M.
Ghosh Shomir
Harrison Sean J.
Hicks Frederick A.
Millennium Pharmaceuticals Inc.
Robic
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