Ph-modified biocompatible monomer and polymer compositions

Details Ph-modified biocompatible monomer and polymer compositions Ph-modified biocompatible monomer and polymer compositions

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61L 24/04 (2006.01) A61L 24/06 (2006.01) A61L 27/00 (2006.01) A61L 27/16 (2006.01) A61L 27/26 (2006.01) C09J 4/00 (2006.01)

Patent

CA 2193968

The pH-modified monomer and polymer compositions are useful as biomedical and surgical adhesives, sealants, implants and bioactive agent release carriers or matrices. They comprise a monomer or polymer; and an effective amount of an acidic or basic pH mofifier effective to modify the pH of an immediate in vivo environment of the composition to a pH range at which the polymer biodegrades at a different rate then at physiologic pH. The invention also relates to in vivo applications in which surfaces are joined or treated with such pH- modified biocompatible compositions.

Les compositions à base de monomère et de polymère modifiées en pH sont utiles en tant qu'adhésifs biomédicaux et chirurgicaux, agents de scellement, implants et supports ou matrices de libération d'agents bioactifs. Elles comprennent un monomère ou un polymère, ainsi qu'une dose efficace d'un modificateur de pH acide ou basique modifiant efficacement le pH d'un environnement in vivo immédiat de la composition en une plage de pH dans laquelle le polymère se dégrade à une vitesse différente par rapport à un pH physiologique. L'invention concerne également des applications in vivo dans lesquelles des surfaces sont unies ou traitées à l'aide de ces compositions biocompatibles modifiées en pH.

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