Ph responsive biodegradable polylactic acid derivatives...

C - Chemistry – Metallurgy – 08 – G

Patent

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C08G 63/08 (2006.01) A61K 9/10 (2006.01) A61K 9/51 (2006.01) A61K 47/34 (2006.01) C08G 63/06 (2006.01) C08G 63/78 (2006.01) C08L 67/04 (2006.01)

Patent

CA 2463517

Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.

L'invention concerne des dérivés d'acide polylactique pouvant former des micelles dans une solution aqueuse présentant un pH égal ou supérieur à 4, lesquels dérivés présentent un groupe carboxyle terminal. Ces dérivés peuvent être appliqués en tant que système d'administration de médicaments sous diverses formes, les médicaments faiblement hydrosolubles pouvant être emprisonnés dans les micelles.

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