Ph-sensitive liposomes

Details Ph-sensitive liposomes Ph-sensitive liposomes

A - Human Necessities

61

K

167/163, 167/103

A61K 48/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2027096

ABSTRACT A pH-sensitive liposome comprising phosphatidyl ethanol amine, and phosphatidic acid and/or phosphatidyl serine in a proportion of not more than 20 mol%, which is characterized in that the molar ratio of phosphatidyl ethanolamine: phos- phatidic acid and/or phosphatidyl serine is 32 : 1-16 is disclosed. The liposomes of the present invention have the pH-sensitivity (responsivity) with the fusion rate increased in the acidic range.

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