Ph sensitive prodrugs of 2,6-diisopropylphenol

Details Ph sensitive prodrugs of 2,6-diisopropylphenol Ph sensitive prodrugs of 2,6-diisopropylphenol

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/497 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 295/18 (2006.01)

Patent

CA 2543166

The present invention is directed to water-soluble derivatives of 2,6- diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6- diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

La présente invention concerne des dérivés hydrosolubles de 2,6-diisopropylphénol (Propofol). Ces composés, qui se comportent comme promédicaments de 2,6-diisopropylphénol, se métabolisent rapidement en Propofol, constituant ainsi une solution de rechange au 2,6-diisopropylphénol insoluble dans l'eau. L'invention concerne également des compositions pharmaceutiques à base de ces composés, des procédés d'induction et d'entretien de l'anesthésie ou de la sédation, ainsi que des procédés permettant le traitement de maladies neurodégénératives au moyen de compositions pharmaceutiques à base de ces compositions, et des procédés pour les élaborer.

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