Ph stable chromatographic media using templated multilayer...

B - Operations – Transporting – 01 – D

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B01D 15/08 (2006.01)

Patent

CA 2581627

An advanced silica gel sorbent for use in chromatographic separations that has been chemically modified by surface polycondensation of a trifunctional and/or difunctional organosilane. The chromatographic media exhibits a wider pH range and improved pH stability as compared to other silica gel based sorbents, while retaining all other positive aspects attributed to silica gel based sorbents. A method of forming the advanced silica gel sorbent by Templated Multilayer Inorganic/Organic Grafting.

La présente invention concerne un sorbant en gel de silice évolué utilisé dans le cadre de séparations chromatographiques. Ce sorbant a été modifié chimiquement par polycondensation superficielle d'un organosilane trifonctionnel et/ou bifonctionnel. Le support chromatographique présente une gamme de pH plus importante et une meilleure stabilité du pH par rapport à d'autres sorbants à base de gel de silice, tout en conservant tous les autres aspects positifs associés aux sorbants à base de gel de silice. Cette invention concerne également un procédé pour produire ledit sorbant en gel de silice évolué par greffage inorganique/organique multicouche gabarié.

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